KSOM Research Seminar Series
Monday, October 24th
at 12 noon in Aresty Auditorium
Timothy J. Triche, MD, PhD
Professor of Pathology, Cancer Biology, and Pediatrics
The Saban Research Institute, Children’s Hospital of Los Angeles
“The Central Role of Non - Coding RNA in Cancer Biology”
Click Here to Watch the Live Webcast!
A light lunch will be served in the foyer at 11:45 am
Abstract: While a great deal of attention has been devoted to DNA mutations, altered methylation, and patterns of mRNA expression in cancer, little attention has been paid to non-coding RNA (ncRNA). In reality, most RNA transcription in the genome is non-coding and recent work from our lab and many others has documented these transcripts are by no means 'transcriptional dark matter', as has been alleged. Rather, they are highly functional, involved in many key processes in development and in cancer biology. Some, like XIST, are vital to X-chromosome inactivation. Others, like HOTAIR, control key processes in metastasis, like epithelial-mesenchymal transition in breast cancer. In the course of our studies of high-risk childhood cancer, we have encountered a plethora of ncRNAs that appear to dictate diagnosis and prognosis. We have studied one transcript in Ewing's sarcoma in particular, AK057037, and have determined it is involved in normal brain development and is a key determinant of the metastatic phenotype. Current work is attempting to elucidate the mechanism(s) by which this occurs.
Keck Research Advancement
(323) 442-7732
